Supporting Evidence
These Are Exceptional Treatments
We offer interventional treatments focused on the best possible results. They are:
Effective
— even for treatment-resistant symptoms
Rapid
— with results in as little as one day or one week of treatment
Durable
— with results that may last indefinitely with periodic maintenance
& Accessible
— including the ability to start treatment quickly, continue taking prescribed medications, and experience minimal side effects
Ketamine
Desktop
70-80% of patients experience rapid and significant relief
These are real scores of depressive symptoms from our patients during their initial series of ketamine infusions
Sustained Results with maintenance every
3-5 weeks
Following the initial series of treatments, results from ketamine may be sustained over time with regular infusions.
We typically start with maintenance infusions every 3-5 weeks. We work with you to find a frequency that helps you sustain positive improvements. When life gets difficult, some patients see us as frequently as every 2 weeks. When things are going well, some patients see as for maintenance as-needed every few months. The frequency of maintenance varies from patients to patient, and with each patient over time.
IV treatment is the most effective delivery method for ketamine, with 100% absorption directly through the bloodstream. It is more effective than intramuscular, intranasal, oral, or sublingual delivery. 4
IV ketamine is more effective than intranasal esketamine (Spravato). 5 Esketamine or S-ketamine is only one half of the ketamine structure, which is composed of both esketamine and its mirror, arketamine (R-ketamine).
IV administration allows for a more comfortable and well-paced patient experience. The controlled pump allows for precise dosing throughout treatment. The infusion can be adjusted or stopped at any time.
Stellate ganglion blocks
Desktop
The remaining 20% of responders see benefit from a left-sided block, or from a block on both sides 8
80% of responders see a majority of benefit from a right-sided block
While many patients see a majority of benefit from a block on one side, a block on both sides — or bilateral blocks — provide the greatest expected benefit. Bilateral blocks may be scheduled as little as one day apart.
same-day
results
Patients may see results as soon as the day of treatment. A stellate ganglion block can calm one’s fight-or-flight response and yield immediate improvement in symptoms.
For patients who do not experience benefit within a week of right-sided treatment, we recommend a subsequent left-sided block to determine if they fall into the subset of patients who see greatest benefit from this side. Patients may also choose to schedule bilateral blocks from the beginning.
For maintenance, we typically see patients every 2-6 months. However, results may sustain indefinitely.
Accelerated TMS
Desktop
Patients can begin to see noticeable changes after approximately 20 sessions of TMS
With conventional daily TMS, patients have treatment once per weekday and may begin to notice changes after approximately
4 weeks
With accelerated TMS, patients have treatment multiple times a day and can begin to notice changes after approximately
2 days
safe and effective
Accelerated TMS is demonstrated to be well-tolerated and equally safe when compared to conventional TMS,
with research that indicates it may also be more effective 11
Nitrous Oxide
Desktop
see benefit within
Nitrous oxide may be a compelling alternate treatment to ketamine.
Like ketamine, nitrous oxide is an NMDA receptor antagonist. Growing research finds that many patients experience a significant reduction in depressive symptoms within 24 hours of treatment, with both acute and cumulative benefit.
One study found that up to 90% of patients experienced a therapeutic response,
with 75% of patients achieving remission of depressive symptoms. 12, 13
mobile
We offer interventional treatments focused on the best possible results. They are:
Effective
— even for treatment-resistant symptoms
Rapid
— with results in as little as one day or one week of treatment
Durable
— with results that may last indefinitely with periodic maintenance
& Accessible
— including the ability to start treatment quickly, continue taking prescribed medications, and experience minimal side effects
Ketamine
mobile
70-80% of patients experience rapid and significant relief
These are real scores of depressive symptoms from our patients during their initial series of ketamine infusions
Sustained Results with maintenance every
3-5 weeks
Following the initial series of treatments, results from ketamine may be sustained over time with regular infusions.
We typically start with maintenance infusions every 3-5 weeks. We work with you to find a frequency that helps you sustain positive improvements. When life gets difficult, some patients see us as frequently as every 2 weeks. When things are going well, some patients see as for maintenance as-needed every few months. The frequency of maintenance varies from patients to patient, and with each patient over time.
IV treatment is the most effective delivery method for ketamine, with 100% absorption directly through the bloodstream. It is more effective than intramuscular, intranasal, oral, or sublingual delivery. 4
IV ketamine is more effective than intranasal esketamine (Spravato). 5 Esketamine or S-ketamine is only one half of the ketamine structure, which is composed of both esketamine and its mirror, arketamine (R-ketamine).
IV administration allows for a more comfortable and well-paced patient experience. The controlled pump allows for precise dosing throughout treatment. The infusion can be adjusted or stopped at any time.
Stellate ganglion blocks
Mobile
80% of responders see a majority of benefit from a right-sided block
The remaining 20% of responders see benefit from a left-sided block, or from a block on both sides 8
While many patients see a majority of benefit from a block on one side, a block on both sides — or bilateral blocks — provide the greatest expected benefit. Bilateral blocks may be scheduled as little as one day apart.
same-day results
Patients may see results as soon as the day of treatment. A stellate ganglion block can calm one’s fight-or-flight response and yield immediate improvement in symptoms.
For patients who do not experience benefit within a week of right-sided treatment, we recommend a subsequent left-sided block to determine if they fall into the subset of patients who see greatest benefit from this side. Patients may also choose to schedule bilateral blocks from the beginning.
For maintenance, we typically see patients every 2-6 months. However, results may sustain indefinitely.
Accelerated TMS
Mobile
Patients can begin to see noticeable changes after approximately 20 sessions of TMS
With conventional daily TMS, patients have treatment once per weekday and may begin to notice changes after approximately
4 weeks
With accelerated TMS, patients have treatment multiple times a day and can begin to notice changes after approximately
2 days
safe and effective
Accelerated TMS is demonstrated to be well-tolerated and equally safe when compared to conventional TMS, with research that indicates it may also be more effective 11
Nitrous Oxide
Mobile
See benefit within
Nitrous oxide may be a compelling alternate treatment to ketamine.
Like ketamine, nitrous oxide is an NMDA receptor antagonist. Growing research finds that many patients experience a significant reduction in depressive symptoms within 24 hours of treatment, with both acute and cumulative benefit.
One study found that up to 90% of patients experienced a therapeutic response,
with 75% of patients achieving remission of depressive symptoms. 12, 13
Our Numbers
Holistic Treatment makes a difference
Studies often seek to analyze the efficacy of interventional treatments on their own — independent of non-controlled factors such as other therapies or lifestyle changes. However, these treatments work even better with a holistic and integrative approach to treatment.
Wells Medicine takes a holistic approach to mental health treatment, with comprehensive and personalized care — and a mission to do ‘whatever it takes’.
In addition to interventional treatments, we offer consultations with your appointments to review factors like your medical history, ongoing treatments, genetics, and lifestyle to evaluate how to best treat your mental health. We can provide a host of resources including referrals, targeted testing services, a personalized integrated support plan, and a collection of free external resources for mental health.
We believe this approach improves the exceptional treatments we provide and helps contribute to our excellent results.
Testimonials
I’ve been receiving treatments from Dr. Wells for almost a year, and I can honestly say she has saved my life. Visiting her office goes beyond just the treatments; Dr. Wells is incredibly knowledgeable about additional therapies, daily practices, and lifestyle changes that have greatly improved my everyday life…
– B. V.
Just wanted to say thank you. I hope you know that you have changed many lives (at least one, which is more than a lot of us will ever do).
– A. E.
Dr. Wells really cares about her patients. She takes time to treat you holistically not just giving you one option. Friendly staff and comfortable atmosphere.
– C. K.
Wells Medicine is my personal and strong recommendation for where you should go for your treatment. The key anesthesiologist, Dr. Wells, is one of the best medical practitioners I have ever met.
– M. B.
Next Steps
Book online to schedule an appointment now (We’ll follow up with more information):
Or contact us to discuss this treatment option further:
References
1. Phillips JL, Norris S, Talbot J, et al. Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial. Focus. 2020;18(2):236-243. doi:10.1176/appi.focus.18206
2. O’Brien, B., Wells, A., Lijffijt, M., Davis, M., Wells, J., Swann, A. C., & Mathew, S. J. The effect of ketamine infusion treatment schedule on depression severity. Poster.
3. Tully JL, Dahlén AD, Haggarty CJ, Schiöth HB, Brooks S. Ketamine treatment for refractory anxiety: A systematic review. Br J Clin Pharmacol. 2022; 88(10): 4412-4426. doi:10.1111/bcp.15374.
4. J.A. Clements, W.S. Nimmo, I.S. Grant. Bioavailability, Pharmacokinetics, and Analgesic Activity of Ketamine in Humans, Journal of Pharmaceutical Sciences, Volume 71, Issue 5, 1982, Pages 539-542, ISSN 0022-3549, https://doi.org/10.1002/jps.2600710516.
5. Bahji A, Vazquez GH, Zarate CA Jr. Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis [published correction appears in J Affect Disord. 2021 Feb 15;281:1001. doi: 10.1016/j.jad.2020.11.103.]. J Affect Disord. 2021;278:542-555. doi:10.1016/j.jad.2020.09.071
6. Lipov EG, Jacobs R, Springer S, Candido KD, Knezevic NN. Utility of Cervical Sympathetic Block in Treating Post-Traumatic Stress Disorder in Multiple Cohorts: A Retrospective Analysis. Pain Physician. 2022;25(1):77-85.
7. Lynch JH, Mulvaney SW, Bryan CJ, Hernandez D. Stellate Ganglion Block Reduces Anxiety Symptoms by Half: A Case Series of 285 Patients. Journal of Personalized Medicine. 2023; 13(6):958. https://doi.org/10.3390/jpm13060958.
8. Sean W Mulvaney, James H Lynch, Kamisha E Curtis, Tamara S Ibrahim, The Successful Use of Left-sided Stellate Ganglion Block in Patients That Fail to Respond to Right-sided Stellate Ganglion Block for the Treatment of Post-traumatic Stress Disorder Symptoms: A Retrospective Analysis of 205 Patients, Military Medicine, Volume 187, Issue 7-8, July-August 2022, Pages e826–e829, https://doi.org/10.1093/milmed/usab056.
9. Cole EJ, Stimpson KH, Bentzley BS, et al. Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression. Am J Psychiatry. 2020;177(8):716-726. doi:10.1176/appi.ajp.2019.19070720.
10. Jithin Thekkelkuthiyathottil Joseph, Rashmi Vishwanath, Samir Kumar Praharaj, Efficacy and safety of accelerated transcranial magnetic stimulation for obsessive-compulsive disorder: A systematic review and meta-analysis, Asian Journal of Psychiatry, Volume 106, 2025, 104420, ISSN 1876-2018, https://doi.org/10.1016/j.ajp.2025.104420.
11. Prato, Michele et al. Accelerated repetitive Transcranial Magnetic Stimulation (aTMS) vs. standard repetitive Transcranial Magnetic Stimulation (rTMS) in the treatment of Major Depressive Episodes: A randomized, single-blind, controlled trial. Transcranial Magnetic Stimulation, Volume 4, 100177. https://doi.org/10.1016/j.transm.2025.100177.
12. Hughes, Marcus E. Nitrous Oxide in the Treatment of Depression: A Brief Review. American Journal of Psychiatry Residents’ Journal, vol. 20, no. 2, American Psychiatric Publishing, Dec. 2024, pp. 18–21, doi:10.1176/appi.ajp-rj.2024.200207. December 6, 2024.
13. Guimarães MC, Guimarães TM, Hallak JE, Abrão J, Machado-de-Sousa JP. Nitrous oxide as an adjunctive therapy in major depressive disorder: a randomized controlled double-blind pilot trial. Braz J Psychiatry. 2021;00:000-000. http://dx.doi.org/10.1590/1516-4446-2020-1543.