Ketamine Infusions

Treatment that provides rapid and significant relief from conditions including depression, anxiety, OCD, and PTSD for many people — even for severe and treatment-resistant symptoms

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Vial of ketamine next to syringe and IV tubing

Significant Relief

70-80% of patients experience a significant reduction in depressive symptoms by their third infusion — even for treatment-resistant symptoms

Broadly Effective

There is a growing body of research evaluating ketamine’s multiple uses as a treatment

Ketamine may effectively treat a variety of conditions, including depression, anxiety, PTSD, OCD, some chronic pain conditions, and more

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Personalized Treatment

Wells Medicine provides IV infusions with precise, controlled, and personalized dosing to make the experience as comfortable and effective as possible

What are ketamine infusions?

Ketamine infusion therapy involves administering a controlled dose of IV ketamine, a medication traditionally used for anesthesia but now recognized for its rapid-acting effects for mental health. This therapy may be used to treat severe depression, including treatment-resistant depression, as well as anxiety, PTSD, and other mood disorders and certain chronic pain conditions such as CRPS.

Why Choose ketamine infusion therapy?

Ketamine infusions provide a clinically-significant reduction of depression symptoms for more than 70% of patients after the third infusion—even in a diverse population and including people suffering from acute, significant and treatment-resistant symptoms. Ketamine infusion treatments can also be similarly helpful for anxiety, PTSD, CRPS and some other mood disorders and pain conditions. Ketamine has a long history as an extremely safe and effective drug. Ketamine infusions are a remarkable breakthrough treatment option for mental health.

IV treatment is the most effective delivery method for ketamine. It is more effective than intramuscular, intranasal (Spravato), oral, or sublingual delivery.

The Procedure

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CONSULTATION

You will fast for a few hours leading up to your appointment. After you’ve checked in and completed a symptom questionnaire, we’ll meet with you in a private treatment room to discuss important information including your symptoms and review any questions you may have about treatment. We will also review other holistic changes that may be helpful to improve your symptoms and increase the benefit you see from the treatment.

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TREATMENT

The provider will set your IV and begin the ketamine treatment, which is a 40-60 minute active infusion. Key vitals, including your heart rate and blood pressure, will be monitored throughout.

Most patients describe IV ketamine treatment as a ‘floaty’ and peaceful journey. Calming music, dim lighting, and items such as a blanket or eye mask can help create a relaxing environment. We work to make the experience as comfortable as possible. We start with a weight-based dose and can adjust the dose and pace of your infusion as-needed. We also provide adjunct medications as appropriate and administer medication to reduce side effects you may experience such as nausea.

After 40-60 minutes, you will hear a beeping noise from the IV pump to indicate that the infusion is finished.

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RECOVERY

After your infusion, you will spend time resting in your room until the immediate effects of the infusion have abated. Side effects generally diminish after about 20 minutes.

When you are ready to leave, you will need a driver to take you home.

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RELIEF

Some patients experience symptom relief after their first infusion. Many patients experience a significant decrease in their symptoms by their third infusion.

Early signs of relief may look like feeling like a weight has lifted off of you, or that getting up in the morning is a little easier. Often, the people around you notice that you are doing better before you do.

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MAINTENANCE

After you’ve completed your sixth infusion, we expect many patients to see the benefit of treatment for 3-5 weeks at a time. Some patients are able to extend their time between ketamine treatments by incorporating other holistic lifestyle changes and other treatments or therapies to improve their mental health.

To sustain the benefit of treatment, we suggest returning for a maintenance infusion every 3-5 weeks or when symptom relief fades.

Induction Series

When starting ketamine treatment for psychiatric symptoms, you’ll begin with an initial series of six ketamine infusions. These treatments are typically spaced close-together, taking place over the course of 2-3 weeks. This treatment schedule is based off of standards established by ketamine research. However, we are happy to work with you to create a treatment schedule that works best for you.

The effect of ketamine is additive. After your first infusion, you may or may not notice a subtle benefit from treatment, such as the feeling of a weight lifted off of you. The beneficial effect of ketamine will feel stronger and last longer after each infusion as your progress through your initial ketamine infusion series.

70-80% of patients experience a significant reduction in their depressive symptoms by their third infusion.

Book your ketamine infusion series

Schedule now or reach out to learn more

Book an Appointment
Call (713) 589 – 5118
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Exceptional Care that Makes a Difference

We are subject matter experts and experience leaders, with many thousands of infusions administered since 2015, having started one of the first ketamine-focused practices in the country (and the first in Houston), and focused on the best and most-current evidence-based care. We focus on compassionate care, and personalized treatment plans that make sense to you. We offer flexible scheduling, Saturday hours, and a convenient location. We’re an excellent choice and we’d be glad to work with you if appropriate.

What Our Patients Say
“I came in for Ketamine therapy without having any idea what I was getting into, only knowing that I wanted to feel better. I had a ton of anxiety but was quickly put at ease by the pleasant staff and the caring and competent doctor. […] She takes a lot of time to explain everything that you’re going to go through, the potential causes of your issues, realistic tools to help fix them, or at least make them less impactful on your overall well being.”
– Patient Testimonial
“The ketamine therapy has been life-changing. I came in dealing with significant anxiety and stress, and over the course of treatment, I’ve experienced a noticeable improvement in my mood, clarity, and overall well-being. It’s not just the treatment itself—the integration, support, and follow-up care are what truly set this practice apart.”
– Patient Testimonial
“This place quiet literally saved my life. I had been struggling with PPD and PMDD for over a year and had seen so many doctors and psychiatrists and no one could figure out how to help me. […] Nothing helped me like talking to Dr. Wells and the treatment combined. If you talk to her about what you are struggling with she gives amazing coping strategies. She is extremely informative and willing to answer any questions you have.”
– Patient Testimonial
“I’ve been receiving treatments from Dr. Wells for almost a year, and I can honestly say she has saved my life. Visiting her office goes beyond just the treatments; Dr. Wells is incredibly knowledgeable about additional therapies, daily practices, and lifestyle changes that have greatly improved my everyday life. Every visit leaves me feeling better than when I arrived”
– Patient Testimonial
“I had been struggling with extreme back pain for months and had honestly become depressed and overwhelmed with a feeling of hopelessness. I met with Dr. Wells and was impressed with her kindness, compassion, and professionalism. I felt very safe and cared for in her hands. My whole life changed after the treatments. They lifted the dark cloud hanging over me and allowed me to be positive in working towards recovery. The treatments were truly a lifesaver!”
– Patient Testimonial
“If you are considering Ketamine therapy, i highly recommend Wells Medicine. There is more to ketamine therapy than just ketamine. There is a safe, comfortable, quiet facility that must be considered as well as the competent staff. I have had several providers and modalities over the past three years. Wells Medicine is the Fort Knox of the gold standard in Ketamine treatment.”
– Patient Testimonial
“I started their ketamine treatment program to help manage my anxiety, and the results have been life-changing. […] After struggling with anxiety for years and trying various other treatments with limited success, ketamine therapy has provided me with a sense of calm and clarity that I never thought possible. Each session is conducted in a relaxing and supportive environment, which has made a huge difference in my overall experience.”
– Patient Testimonial

Common questions

Interested in joining ketamine research?

Wells Medicine is helping to conduct research on ketamine infusion therapy. These studies are important for developing our understanding of mental health conditions and ketamine therapy for mood disorders.
Study enrollment may provide some compensation for participation. Patients new to ketamine or returning to treatment may be eligible.

Learn More

More on ketamine infusions

A ketamine infusion is a therapeutic procedure where a low dose of ketamine, a medication originally used as an anesthetic, is administered intravenously. This treatment is carried out by experienced providers under clinical guidelines and with appropriate monitoring to ensure safety and efficacy. The infusion process typically lasts between 40 to 60 minutes and is performed in an out-patient clinical setting. Ketamine has emerged as a breakthrough therapy for those suffering from severe depression, including treatment-resistant symptoms, as well as other mood disorders. It has also been shown to be effective for various chronic pain syndromes, like CRPS. Research on the use of ketamine for mental health began over two decades ago and has accelerated significantly in the last 10 years, providing a new hope for rapid symptom relief and improved quality of life. Unlike traditional treatments, ketamine can offer immediate benefits, making it a great option for those who have not found relief with other therapies. Some people see benefits immediately following their first treatment—especially those suffering with acute symptoms such as persistent suicidal ideation. Many people see benefits that build over multiple treatments, and many report measurable improvements after just a few treatments. We often see patients for an initial series of 6 treatments over a few weeks followed by maintenance treatments every 3 to 5 weeks thereafter to sustain the results.

Ketamine is FDA-approved for use as a general anesthetic. Its use for psychiatric conditions and pain conditions is considered an off-label application. Individual results vary. Ketamine treatments should not be considered a replacement for medication management, psychotherapy, or other standards of care.

What does ketamine treat?

Depression, severe depression, & TRD

Anxiety, severe anxiety, & generalized anxiety

OCD / Obsessive-Compulsive Disorder

PTSD / Post-Traumatic Stress Disorder

Bipolar II

Acute or chronic suicidal ideation

Substance use disorders

Eating disorders

Other mood disorders

Neuropathic pain

Central sensitization

Chronic migraines

CRPS / Complex Regional Pain Syndrome

RSD / Reflex Sympathetic Dystrophy

Fibromyalgia

Cancer pain syndromes

Phantom limb pain

Chronic pelvic pain

Some other chronic pain syndromes

& other conditions

How does it work?

For mood: As with many drugs, the exact mechanisms of action are not perfectly understood, but there is significant research on this topic and compelling models. Ketamine acts as an NMDA receptor antagonist and this is thought to be one of its principal areas of action with respect to mood disorders and blocking rumination in the default mode network. Ketamine also acts on other pathways, which may explain its myriad effects in the central and peripheral nervous system, including: the mTOR pathway, the AMPA receptor pathway, and even the opioid receptors in the brain.

For pain: Ketamine has been shown to work for neurological pain conditions such CRPS and other conditions originating in or related to the nerves themselves (and not caused by ongoing physical damage). Ketamine works on chronic pain through many actions, including down-regulating the mu opioid receptors, decreasing central sensitization, it is a potent anti-inflammatory, and it may decrease our subjective experience of pain.

With the caveat that the exact action is not fully understood, our best working model for how we understand ketamine seems to work is this:

1. Ketamine encourages neural growth and connectivity

2. The increased neural activity likely helps affected neurons, including the brain, to function more optimally

3. The increased neural activity also promotes neuroplasticity—where neurons make new connections, allowing a patient’s neural activity to overcome unhealthy recursive patterns: This may help a depressed patient to reduce or get away from recursive negative thoughts. It may help a patient with OCD to take advantage of aversion therapy. It may help a substance abuse patient to more readily establish healthy thoughts and routines outside of their addictive behaviors. It may help a pain patient to get out of a pain feedback loop.

Benefits of ketamine

Highly Effective:

Ketamine treatments provide significant relief for many people, even for treatment-resistant symptoms. It offers new hope to individuals where other treatments have failed.

Fast-Acting:

Patients may report a significant reduction in symptoms even within hours after the first infusion, with many people noticing significant improvements after a few treatments.

Durable Results:

Results last over time and may be sustained indefinitely with maintenance treatments. There is no daily pill to remember, and no daily side effects that come along with it.

compatible treatment:

There is no need to stop your existing medications or treatments. Ketamine treatments may be pursued in addition to or alongside other approaches to your care.

Multiple indications:

Ketamine infusions work systemically—throughout your whole body—and may be helpful in treating more than one condition at the same time.

Review the Evidence

Risks & Side Effects

Like any medical procedure, ketamine infusions come with potential risks and side effects. Most are temporary and may include:

Common: Feelings of dizziness during and shortly after the infusion. Patients often describe this as ‘feeling floaty.’

Less Common: Nausea and mild hallucinogenic effects, which typically resolve soon after the treatment. Patients sometimes describe ‘seeing colors’ or similar transitory effects. Elevated blood pressure and heart rate.

We monitor for these effects and side-effects during the infusions to immediately manage any risks or discomfort.

While ketamine is considered a safe drug in medical clinics or hospitals, it is still a very serious drug and should be used in appropriate settings with appropriate safeguards in place. Ketamine should be provided by professionals trained in its use and with emergency equipment, medications and contingency plans in place. Ketamine should not be used in a home setting. It is even important to review the qualifications of clinical providers who provide treatments.

Alternatives to ketamine infusions

For patients considering alternative treatments, options may include conventional antidepressants, psychotherapy, electroconvulsive therapy (ECT), and transcranial magnetic stimulation (TMS). Each alternative has its own set of benefits and considerations, and the best choice will depend on individual patient needs and medical history.

Ketamine has few contraindications and does not conflict with or prohibit the use of most other treatments or therapies. It is often appropriate to pursue some other treatments while receiving ketamine treatments. In fact, it can be especially helpful to pursue psychotherapy while receiving ketamine infusion therapies and we even offer Ketamine Assisted Psychotherapy for this very purpose.

Research

There is a large and growing body of research on ketamine infusion treatments. A good starting point is our research page, which includes analysis of our own clinical data from the infusions we have provided.

Recent research supports a variety of uses and broad efficacy:

New studies show that ketamine is effective in treating treatment-resistant anxiety, even in a population that has both treatment-resistant anxiety and treatment-resistant depression, which is generally understood to be more difficult to treat due to more severe symptoms and higher probability of relapse.

Recent studies have reinforced ketamine’s capacity to rapidly reduce symptoms of suicidality. For patients with suicidal ideation or thoughts, 78 percent showed gradual or rapid improvement of symptoms following intravenous (IV) ketamine treatment.

Learn more about ketamine treatment

Ketamine Blog Posts

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