One-Day vs One-Week Accelerated TMS

One-Day and One-Week TMS are accelerated versions of TMS. They are designed to be fast-acting and more accessible for patient’s schedules. There are some differences in how these treatments work and what they can treat.

What is accelerated TMS?

The accelerated protocol was developed at Stanford University and is often referred to as the SAINT Protocol, for Stanford Accelerated Intelligent Neuromodulation Therapy. This innovative approach was designed to deliver a high-dose, high-frequency regimen of TMS over a compressed time frame, producing rapid and significant improvements in symptoms. While the researchers behind the protocol have commercialized their work and trademarked the SAINT acronym, the core principles of the protocol are derived from peer-reviewed and published research and techniques, and others can implement accelerated TMS methodologies within the scope of existing evidence-based practices.

We offer an accelerated protocol that adheres to the established principles of intensive neuromodulation therapy. The key aspects of this approach are multiple sessions per day over a condensed period, targeting specific areas of the brain to achieve rapid symptom relief. This approach is grounded in the scientific literature and mirrors the rigorous protocols outlined in the original SAINT studies, while incorporating current best practices and details specific to each patient for efficacy, safety, and patient comfort. 

Indications

Accelerated protocols are still being researched and more will continue to emerge over time.

Currently, the following indications exist for TMS:

  • One-Day TMS: Severe depression & suicidal ideation
  • One-Week TMS: Severe depression & suicidal ideation, OCD, and anxiety
  • Conventional TMS: Severe depression & suicidal ideation, OCD, anxiety, migraines, smoking cessation, PTSD, bipolar disorder, some pain conditions, and some other psychiatric conditions

We expect to see many of the protocols of conventional TMS to become available in One-Week TMS as research progresses, and eventually in One-Week TMS as well.

Treatment schedule

The schedules of accelerated TMS treatments are in the name. One-Day TMS is completed within one day, while One-Week TMS is completed within one business week or five days of treatment.

One-Day TMS involves 20 treatments over one day within approximately 10 hours, with breaks in between treatments.

One-Week TMS involves 50 treatments over the course of five days, with 10 treatments each day. Treatment days last approximately 10 hours, with breaks in between treatments.

Conventional TMS is conducted once a day over the course of 4-6 weeks or longer, totaling 30-36 treatments.

Adjunct medications

During One-Day TMS, patients additionally take adjunct medications D-cycloserine and lisdexamfetamine (Vyvanse) to increase neuroplasticity. This effect on neuroplasticity is similar to the effect of ketamine treatment: it can decrease rumination and break fight-or-flight loops by creating new neural pathways. Therapy can take advantage of this state of neuroplasticity and help patients consciously choose what thought patterns to break and how to create new patterns.

One-Week TMS and conventional TMS similarly create neuroplasticity, but do not require adjunct medications during treatment.

One-Day TMS

One-Week TMS

Protocols

Depression

Depression, Anxiety, OCD

Treatment Duration

1 day

5 days

Session #

20 sessions

50 sessions

Enhancements

D-cycloserine and lisdexamfetamine to enhance neuroplasticity

N/A

Traditional TMS has proven to be a good treatment option, however, the support for newer accelerated versions of TMS is overwhelming. Both One-Day and One-Week TMS are excellent treatment options for symptoms and some mood conditions that don’t go away with medication and treatment trials. These protocols use the best of what we know of TMS treatment efficacy.

About Us

Wells Medicine is a Houston-based practice designed to provide meaningful care for mental health. Providing targeted interventional treatments for Depression, Anxiety, OCD, PTSD and other conditions, with Ketamine Treatments, Stellate Ganglion Blocks, TMS, and Nitrous-Oxide Treatments. Focused on comprehensive care and integration with Psychiatry, Psychology, and Support Services. We are evidence-based, patient-focused and mission-driven.

The content here is for informational purposes and should not be relied upon for medical decisions. For the details of your specific medical conditions and treatments consult your doctors or other qualified healthcare professionals.